The Shire of Murrindindi is a local government area in the Hume region of Victoria, Australia, located in the north-east part of the state. It covers an area of 3,880 square kilometres (1,500 sq mi) and, in June 2018, had a population of 14,478. It includes the towns of Alexandra, Buxton, Eildon, Flowerdale, Kinglake, Marysville, Molesworth, Strath Creek, Taggerty, Yarck and Yea. It was formed in 1994 from the amalgamation of the Shire of Alexandra, Shire of Yea, and parts of the Shire of Broadford, Shire of Eltham, Shire of Euroa, Shire of Healesville and City of Whittlesea.
The Shire is governed by the Murrindindi Shire Council; its seat of local government and administrative centre is located at the council headquarters in Alexandra, it also has service centres located in Kinglake and Yea. The Shire is named after the locality of Murrindindi, which is located near the geographical centre of the LGA.
Parts of Murrindindi were badly affected by the 2009 Victorian bushfires, notably the towns of Marysville and Kinglake. In total, 106 people lost their lives across the Shire including 38 in Kinglake and 34 in Marysville.